Life Steal: Heals you for Diablo 4 Gold a percentage of your damage dealt.
On Kill Effects: Certain affixes activate bonuses or effects when you kill enemies, like generating resources, healing, or granting buffs.
Crowd Control Resistance: Reduces the duration or chance of being affected by crowd control effects (e.g., stuns, slow).
Prioritize Affixes Based on Your Build
Your character's build (class, playstyle, and role) will determine which affixes to prioritize.

A. Damage-Focused Builds
For DPS (damage-dealing) builds, you’ll want to focus on affixes that increase damage output and attack efficiency.

Critical Strike Chance and Critical Strike Damage are a must-have for increasing burst damage.
Elemental Damage should align with the elements you’re using in your abilities (e.g., Fire if you're a Fire Sorcerer).
Attack Speed increases the number of attacks you can make in a short time, directly increasing your damage.
B. Tank Builds
For tank or defensive builds, you should focus on affixes that boost your defense and survivability.

Armor and Damage Reduction are crucial for reducing incoming damage.
Life on Hit and Life Steal help sustain health during combat.
Resistance to elemental damage types ensures you’re prepared for specific environmental hazards or enemy types.
C. Hybrid or Support Builds
If your build is hybrid (damage + support), you'll need a balance of both offensive and defensive affixes.

Cooldown Reduction is crucial for maximizing the frequency of support abilities or high-damage attacks.
Resource Generation helps you maintain the flow of abilities.
Crowd Control Resistance allows you to avoid being hindered during crucial moments.
Affix Synergies and Combinations
Maximizing the potential of affixes isn’t just about choosing individual affixes; you need to look at synergies between different affixes.

Synergize with Abilities: Some affixes directly enhance your core abilities. For example, if you use a poison-based build, look for affixes that increase poison damage or damage over time effects.
Support Multiple Effects: Combine offensive and defensive affixes to create a more well-rounded build. For example, if you’re playing a Necromancer with minions, try combining minion damage affixes with damage reduction affixes for survivability.
Look for Set Bonuses: Set bonuses often provide additional synergy for your affixes, stacking specific effects for buy D4 Gold even greater power.